Assay Detail
Functional
CHEMBL856058
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Tested for cytotoxicity against C170 colorectal carcinoma cell line by [75Se]selenomethionine uptake assay, in vitro
8
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | C170 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of 2'-deoxyuridine and 5-fluoro-2'-deoxyuridine derivatives and evaluation in antibody targeting studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.50 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL917 | FLOXURIDINE | 4.0 | 2 | 6.40 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 2 | 5.70 |
| CHEMBL2368643 | RIBOFURANURONIC ACID | — | 2 | 4.39 |
| CHEMBL2368647 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL917 | FLOXURIDINE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2368643 | RIBOFURANURONIC ACID | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL2368643 | RIBOFURANURONIC ACID | IC50 | = | 10.0 | ug.mL-1 | - |
| CHEMBL2368647 | — | IC50 | = | 26.0 | ug.mL-1 | - |
| CHEMBL2368647 | — | IC50 | = | 107000.0 | nM | - |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 0.3 | ug.mL-1 | - |
| CHEMBL917 | FLOXURIDINE | IC50 | = | 0.1 | ug.mL-1 | - |