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Assay Detail

CHEMBL856071

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Concentration required for inhibition of C3H10T1/2 progenitor cell growth
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type C3H 10T1/2
Confidence 1 — Organism
Curated By Expert

Target

C3H 10T1/2 (CHEMBL614531)
Type CELL-LINE
Organism Mus musculus

Publication

Ascochlorin derivatives as ligands for nuclear hormone receptors.
Togashi M, Ozawa S, Abe S, Nishimura T, Tsuruga M, Ando K, Tamura G, Kuwahara S, Ubukata M, Magae J.
J Med Chem (2003) 46 : 4113 -4123
PubMed 12954063 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 29 4.97 6.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL133334 1 6.22
CHEMBL132623 ASCOCHLORIN 1 6.00
CHEMBL131153 1 5.75
CHEMBL334949 1 5.50
CHEMBL133046 ASCOFURANONE 1 5.50
CHEMBL134146 1 5.50
CHEMBL134093 1 5.33
CHEMBL130579 1 5.25
CHEMBL336722 1 5.25
CHEMBL133917 1 5.25
CHEMBL131694 1 5.25
CHEMBL134031 1 5.00
CHEMBL337190 1 5.00
CHEMBL133351 1 5.00
CHEMBL423526 1 5.00
CHEMBL337716 1 5.00
CHEMBL336558 1 5.00
CHEMBL133045 1 4.75
CHEMBL134174 1 4.75
CHEMBL337202 1 4.75
CHEMBL280438 1 4.50
CHEMBL133645 1 4.50
CHEMBL336516 1 4.43
CHEMBL338269 1 4.42
CHEMBL131450 1 4.25
CHEMBL133882 1 4.25
CHEMBL129991 1 4.25
CHEMBL134249 1 4.25
CHEMBL132134 1 4.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL133334 IC50 = 600.0 nM 6.22
CHEMBL132623 ASCOCHLORIN IC50 = 1000.0 nM 6.00
CHEMBL131153 IC50 = 1800.0 nM 5.75
CHEMBL334949 IC50 = 3200.0 nM 5.50
CHEMBL133046 ASCOFURANONE IC50 = 3200.0 nM 5.50
CHEMBL134146 IC50 = 3200.0 nM 5.50
CHEMBL134093 IC50 = 4700.0 nM 5.33
CHEMBL130579 IC50 = 5600.0 nM 5.25
CHEMBL336722 IC50 = 5600.0 nM 5.25
CHEMBL133917 IC50 = 5600.0 nM 5.25
CHEMBL131694 IC50 = 5600.0 nM 5.25
CHEMBL134031 IC50 = 10000.0 nM 5.00
CHEMBL337190 IC50 = 10000.0 nM 5.00
CHEMBL133351 IC50 = 10000.0 nM 5.00
CHEMBL423526 IC50 = 10000.0 nM 5.00
CHEMBL337716 IC50 = 10000.0 nM 5.00
CHEMBL336558 IC50 = 10000.0 nM 5.00
CHEMBL133045 IC50 = 18000.0 nM 4.75
CHEMBL134174 IC50 = 18000.0 nM 4.75
CHEMBL337202 IC50 = 18000.0 nM 4.75
CHEMBL280438 IC50 = 32000.0 nM 4.50
CHEMBL133645 IC50 = 32000.0 nM 4.50
CHEMBL336516 IC50 = 37000.0 nM 4.43
CHEMBL338269 IC50 = 38000.0 nM 4.42
CHEMBL131450 IC50 = 56000.0 nM 4.25
CHEMBL133882 IC50 = 56000.0 nM 4.25
CHEMBL129991 IC50 = 56000.0 nM 4.25
CHEMBL134249 IC50 = 56000.0 nM 4.25
CHEMBL132134 IC50 = 56000.0 nM 4.25