Assay Detail
Binding
CHEMBL856198
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Inhibition concentration against HIV-1 protease
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Cyclic HIV-1 protease inhibitors derived from mannitol: synthesis, inhibitory potencies, and computational predictions of binding affinities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.48 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL354502 | — | — | 1 | 8.00 |
| CHEMBL21145 | DMP-323 | — | 1 | 7.82 |
| CHEMBL171148 | — | — | 1 | 7.10 |
| CHEMBL130998 | — | — | 1 | 6.70 |
| CHEMBL170517 | — | — | 1 | 6.70 |
| CHEMBL69731 | — | — | 1 | 5.40 |
| CHEMBL171235 | — | — | 1 | 5.10 |
| CHEMBL355782 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL354502 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL21145 | DMP-323 | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL171148 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL130998 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL170517 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL69731 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL171235 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL355782 | — | IC50 | = | 10000.0 | nM | 5.00 |