Assay Detail
Functional
CHEMBL856238
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cAMP production in HeLa cells expressing human 5-HT6 receptor
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conformationally constrained N1-arylsulfonyltryptamine derivatives as 5-HT6 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.58 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL194307 | — | — | 1 | 9.22 |
| CHEMBL371886 | — | — | 1 | 9.10 |
| CHEMBL413525 | — | — | 1 | 9.00 |
| CHEMBL194750 | — | — | 1 | 8.14 |
| CHEMBL198941 | — | — | 1 | 8.14 |
| CHEMBL427184 | — | — | 1 | 8.12 |
| CHEMBL196094 | — | — | 1 | 8.09 |
| CHEMBL369910 | — | — | 1 | 7.96 |
| CHEMBL194590 | — | — | 1 | 7.81 |
| CHEMBL380556 | — | — | 1 | 7.68 |
| CHEMBL383373 | — | — | 1 | 7.61 |
| CHEMBL370507 | — | — | 1 | 7.60 |
| CHEMBL193450 | — | — | 1 | 7.36 |
| CHEMBL198827 | — | — | 1 | 7.30 |
| CHEMBL193358 | — | — | 1 | 7.28 |
| CHEMBL425196 | — | — | 1 | 7.27 |
| CHEMBL370215 | — | — | 1 | 7.25 |
| CHEMBL380772 | — | — | 1 | 7.21 |
| CHEMBL371469 | — | — | 1 | 7.12 |
| CHEMBL196102 | — | — | 1 | 7.09 |
| CHEMBL365774 | — | — | 1 | 7.07 |
| CHEMBL195018 | — | — | 1 | 7.02 |
| CHEMBL196619 | — | — | 1 | 7.01 |
| CHEMBL365753 | — | — | 1 | 6.97 |
| CHEMBL196466 | — | — | 1 | 6.96 |
| CHEMBL366012 | — | — | 1 | 6.96 |
| CHEMBL434932 | — | — | 1 | 6.95 |
| CHEMBL194786 | — | — | 1 | 6.91 |
| CHEMBL371292 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL194307 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL371886 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL413525 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL194750 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL198941 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL427184 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL196094 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL369910 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL194590 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL380556 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL383373 | — | IC50 | = | 24.5 | nM | 7.61 |
| CHEMBL370507 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL193450 | — | IC50 | = | 43.6 | nM | 7.36 |
| CHEMBL198827 | — | IC50 | = | 49.5 | nM | 7.30 |
| CHEMBL193358 | — | IC50 | = | 52.5 | nM | 7.28 |
| CHEMBL425196 | — | IC50 | = | 53.3 | nM | 7.27 |
| CHEMBL370215 | — | IC50 | = | 56.3 | nM | 7.25 |
| CHEMBL380772 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL371469 | — | IC50 | = | 76.5 | nM | 7.12 |
| CHEMBL196102 | — | IC50 | = | 81.4 | nM | 7.09 |
| CHEMBL365774 | — | IC50 | = | 85.5 | nM | 7.07 |
| CHEMBL195018 | — | IC50 | = | 96.2 | nM | 7.02 |
| CHEMBL196619 | — | IC50 | = | 96.7 | nM | 7.01 |
| CHEMBL365753 | — | IC50 | = | 107.1 | nM | 6.97 |
| CHEMBL196466 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL366012 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL434932 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL194786 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL371292 | — | IC50 | = | - | nM | - |