Assay Detail
Functional
CHEMBL856242
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Half maximal inhibitory concentration against estrogen-induced proliferation of MCF-7 breast cells by 10 pM E2
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
A selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.23 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL539849 | — | — | 1 | 9.70 |
| CHEMBL537638 | — | — | 1 | 9.47 |
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | 4.0 | 1 | 9.43 |
| CHEMBL536733 | — | — | 1 | 9.07 |
| CHEMBL557981 | — | — | 1 | 8.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL539849 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL537638 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL536733 | — | IC50 | = | 0.86 | nM | 9.07 |
| CHEMBL557981 | — | IC50 | = | 3.4 | nM | 8.47 |