Assay Detail
Functional
CHEMBL856244
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Inhibitory concentration required for antiproliferative activity against human MDA-MB-231 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of a resveratrol analogue with high ceramide-mediated proapoptotic activity on human breast cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.94 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296411 | TRISMETHOXYRESVERATROL | — | 1 | 5.92 |
| CHEMBL362997 | — | — | 1 | 5.14 |
| CHEMBL83527 | PTEROSTILBENE | 2.0 | 1 | 5.00 |
| CHEMBL197892 | — | — | 1 | 4.90 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 4.69 |
| CHEMBL194577 | — | — | 1 | 4.55 |
| CHEMBL194888 | — | — | 1 | 4.35 |
| CHEMBL291501 | RESVERATROL 4'-METHYL ETHER | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296411 | TRISMETHOXYRESVERATROL | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL362997 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL83527 | PTEROSTILBENE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL197892 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL165 | RESVERATROL | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL194577 | — | IC50 | = | 28300.0 | nM | 4.55 |
| CHEMBL194888 | — | IC50 | = | 45100.0 | nM | 4.35 |
| CHEMBL291501 | RESVERATROL 4'-METHYL ETHER | IC50 | > | 50000.0 | nM | - |