Assay Detail
Functional
CHEMBL856253
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against Src-transformed fibroblast proliferation
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-Anilino-7,8-dialkoxybenzo[g]quinoline-3-carbonitriles as potent Src kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.93 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL196797 | — | — | 1 | 8.00 |
| CHEMBL370633 | — | — | 1 | 7.72 |
| CHEMBL198868 | — | — | 1 | 7.66 |
| CHEMBL436486 | — | — | 1 | 7.55 |
| CHEMBL195029 | — | — | 1 | 7.43 |
| CHEMBL196889 | — | — | 1 | 7.38 |
| CHEMBL427544 | — | — | 1 | 7.32 |
| CHEMBL425389 | — | — | 1 | 7.30 |
| CHEMBL198650 | — | — | 1 | 7.21 |
| CHEMBL198084 | — | — | 1 | 7.15 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 7.00 |
| CHEMBL372552 | — | — | 1 | 6.96 |
| CHEMBL194352 | — | — | 1 | 6.75 |
| CHEMBL335025 | — | — | 1 | 6.68 |
| CHEMBL196411 | — | — | 1 | 6.66 |
| CHEMBL198211 | — | — | 1 | 6.64 |
| CHEMBL194969 | — | — | 1 | 6.58 |
| CHEMBL197713 | — | — | 1 | 6.57 |
| CHEMBL197744 | — | — | 1 | 6.46 |
| CHEMBL196474 | — | — | 1 | 6.01 |
| CHEMBL197930 | — | — | 1 | 5.80 |
| CHEMBL197715 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL196797 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL370633 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL198868 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL436486 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL195029 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL196889 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL427544 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL425389 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL198650 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL198084 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL372552 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL194352 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL335025 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL196411 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL198211 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL194969 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL197713 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL197744 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL196474 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL197930 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL197715 | — | IC50 | = | 2000.0 | nM | 5.70 |