Assay Detail
Binding
CHEMBL856312
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human NHE2 expressed in Ap1 cell line
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Ap1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.68 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL217698 | — | — | 1 | 5.05 |
| CHEMBL64360 | ENIPORIDE | 2.0 | 1 | 4.77 |
| CHEMBL436559 | CARIPORIDE | 2.0 | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL217698 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL64360 | ENIPORIDE | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL436559 | CARIPORIDE | IC50 | = | 62000.0 | nM | 4.21 |