Assay Detail
Functional
CHEMBL856448
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Antiproliferative activity measured against PC-3 human prostate adenocarcinoma
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Prostate gland |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Homocamptothecins: synthesis and antitumor activity of novel E-ring-modified camptothecin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.44 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150195 | — | — | 1 | 9.24 |
| CHEMBL345989 | — | — | 1 | 8.44 |
| CHEMBL348711 | — | — | 1 | 7.92 |
| CHEMBL150850 | — | — | 1 | 7.75 |
| CHEMBL151419 | — | — | 1 | 7.55 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.24 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 6.80 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.41 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.64 |
| CHEMBL149851 | — | — | 1 | - |
| CHEMBL358471 | — | — | 1 | - |
| CHEMBL151912 | — | — | 1 | - |
| CHEMBL345998 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150195 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL345989 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL348711 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL150850 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL151419 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL149851 | — | IC50 | < | 0.001 | nM | - |
| CHEMBL358471 | — | IC50 | < | 0.001 | nM | - |
| CHEMBL151912 | — | IC50 | = | 0.001 | nM | - |
| CHEMBL345998 | — | IC50 | < | 0.001 | nM | - |