Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL856485

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of PKA-mediated phosphorylation of kemptide at 100 uM
20
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

cAMP-dependent protein kinase (PKA) (CHEMBL2094138)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Synthesis of highly substituted dibenzo[b,f]azocines and their evaluation as protein kinase inhibitors.
Arnold LA, Kiplin Guy R.
Bioorg Med Chem Lett (2006) 16 : 5360 -5363
PubMed 16890431 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Activity 18 - -
IC50 2 5.92 5.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL104264 1 5.92
CHEMBL219082 1 -
CHEMBL436532 1 -
CHEMBL219526 1 -
CHEMBL375547 1 -
CHEMBL387031 1 -
CHEMBL218307 1 -
CHEMBL220355 1 -
CHEMBL373764 1 -
CHEMBL219447 1 -
CHEMBL219254 1 -
CHEMBL218409 1 -
CHEMBL375401 1 -
CHEMBL218802 1 -
CHEMBL220071 1 -
CHEMBL219402 1 -
CHEMBL216984 1 -
CHEMBL387009 1 -
CHEMBL218747 1 -
CHEMBL384412 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL104264 IC50 = 1200.0 nM 5.92
CHEMBL219082 Activity - -
CHEMBL436532 Activity - -
CHEMBL219526 Activity - -
CHEMBL375547 Activity - -
CHEMBL387031 Activity - -
CHEMBL218307 Activity - -
CHEMBL220355 Activity - -
CHEMBL373764 Activity - -
CHEMBL219447 Activity - -
CHEMBL219254 Activity - -
CHEMBL218409 Activity - -
CHEMBL375401 Activity - -
CHEMBL218802 Activity - -
CHEMBL220071 Activity - -
CHEMBL219402 Activity - -
CHEMBL216984 Activity - -
CHEMBL387009 Activity - -
CHEMBL218747 IC50 = 122000.0 nM -
CHEMBL384412 Activity - -