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Assay Detail

CHEMBL856486

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Functional
Antiviral activity against BVDV NADL in MDBK cells
ChEMBL ↗
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Bovine viral diarrhea virus 1
Cell Type MDBK
Confidence 1 — Organism
Curated By Intermediate

Target

Bovine viral diarrhea virus 1 (CHEMBL612571) ↗
Type ORGANISM
Organism Bovine viral diarrhea virus 1

Publication

Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors.
Puerstinger G, Paeshuyse J, Herdewijn P, Rozenski J, De Clercq E, Neyts J.
Bioorg Med Chem Lett (2006) 16 : 5345 -5349
PubMed 16901692 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 54 6.22 7.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL216780 — — 1 7.22
CHEMBL374556 — — 1 7.16
CHEMBL219515 — — 1 7.10
CHEMBL219242 — — 1 7.10
CHEMBL373550 — — 1 7.00
CHEMBL218801 — — 1 6.96
CHEMBL219200 — — 1 6.92
CHEMBL385366 — — 1 6.92
CHEMBL216920 — — 1 6.89
CHEMBL219383 — — 1 6.85
CHEMBL219052 — — 1 6.82
CHEMBL385089 — — 1 6.77
CHEMBL216795 — — 1 6.72
CHEMBL219422 — — 1 6.68
CHEMBL426166 — — 1 6.68
CHEMBL218903 — — 1 6.66
CHEMBL218018 — — 1 6.64
CHEMBL219506 — — 1 6.64
CHEMBL216797 — — 1 6.62
CHEMBL219604 — — 1 6.60
CHEMBL216975 — — 1 6.57
CHEMBL386158 — — 1 6.57
CHEMBL220353 — — 1 6.57
CHEMBL425108 — — 1 6.55
CHEMBL218937 — — 1 6.55
CHEMBL219605 — — 1 6.52
CHEMBL219579 — — 1 6.31
CHEMBL415050 — — 1 6.30
CHEMBL216919 — — 1 6.22
CHEMBL216892 — — 1 6.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL216780 — EC50 = 60.0 nM 7.22
CHEMBL374556 — EC50 = 70.0 nM 7.16
CHEMBL219242 — EC50 = 80.0 nM 7.10
CHEMBL219515 — EC50 = 80.0 nM 7.10
CHEMBL373550 — EC50 = 100.0 nM 7.00
CHEMBL218801 — EC50 = 110.0 nM 6.96
CHEMBL219200 — EC50 = 120.0 nM 6.92
CHEMBL385366 — EC50 = 120.0 nM 6.92
CHEMBL216920 — EC50 = 130.0 nM 6.89
CHEMBL219383 — EC50 = 140.0 nM 6.85
CHEMBL219052 — EC50 = 150.0 nM 6.82
CHEMBL385089 — EC50 = 170.0 nM 6.77
CHEMBL216795 — EC50 = 190.0 nM 6.72
CHEMBL426166 — EC50 = 210.0 nM 6.68
CHEMBL219422 — EC50 = 210.0 nM 6.68
CHEMBL218903 — EC50 = 220.0 nM 6.66
CHEMBL218018 — EC50 = 230.0 nM 6.64
CHEMBL219506 — EC50 = 230.0 nM 6.64
CHEMBL216797 — EC50 = 240.0 nM 6.62
CHEMBL219604 — EC50 = 250.0 nM 6.60
CHEMBL216975 — EC50 = 270.0 nM 6.57
CHEMBL386158 — EC50 = 270.0 nM 6.57
CHEMBL220353 — EC50 = 270.0 nM 6.57
CHEMBL425108 — EC50 = 280.0 nM 6.55
CHEMBL218937 — EC50 = 280.0 nM 6.55
CHEMBL219605 — EC50 = 300.0 nM 6.52
CHEMBL219579 — EC50 = 490.0 nM 6.31
CHEMBL415050 — EC50 = 500.0 nM 6.30
CHEMBL216919 — EC50 = 600.0 nM 6.22
CHEMBL216892 — EC50 = 700.0 nM 6.16
CHEMBL218800 — EC50 = 760.0 nM 6.12
CHEMBL218034 — EC50 = 850.0 nM 6.07
CHEMBL219057 — EC50 = 1500.0 nM 5.82
CHEMBL216858 — EC50 = 1500.0 nM 5.82
CHEMBL375219 — EC50 = 1600.0 nM 5.80
CHEMBL374340 — EC50 = 1700.0 nM 5.77
CHEMBL219961 — EC50 = 1900.0 nM 5.72
CHEMBL374033 — EC50 = 2000.0 nM 5.70
CHEMBL376739 — EC50 = 2100.0 nM 5.68
CHEMBL220412 — EC50 = 2100.0 nM 5.68
CHEMBL424930 — EC50 = 2200.0 nM 5.66
CHEMBL218033 — EC50 = 3000.0 nM 5.52
CHEMBL425989 — EC50 = 3800.0 nM 5.42
CHEMBL219173 — EC50 = 4000.0 nM 5.40
CHEMBL373551 — EC50 = 4000.0 nM 5.40
CHEMBL218936 — EC50 = 5000.0 nM 5.30
CHEMBL348812 — EC50 = 10000.0 nM 5.00
CHEMBL374086 — EC50 = 15000.0 nM 4.82
CHEMBL384105 — EC50 = 16200.0 nM 4.79
CHEMBL374036 — EC50 = 57000.0 nM 4.24