Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL856512

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of DPP4
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Dipeptidyl peptidase 4 (CHEMBL284)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors.
Xu J, Wei L, Mathvink RJ, Edmondson SD, Eiermann GJ, He H, Leone JF, Leiting B, Lyons KA, Marsilio F, Patel RA, Patel SB, Petrov A, Scapin G, Wu JK, Thornberry NA, Weber AE.
Bioorg Med Chem Lett (2006) 16 : 5373 -5377
PubMed 16919457 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 36 6.47 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL386812 1 8.10
CHEMBL376498 1 7.89
CHEMBL219371 1 7.89
CHEMBL216835 1 7.77
CHEMBL375745 1 7.72
CHEMBL387333 1 7.72
CHEMBL218776 1 7.72
CHEMBL375146 1 7.72
CHEMBL219434 1 7.51
CHEMBL435320 1 7.40
CHEMBL219278 1 7.37
CHEMBL375442 1 7.28
CHEMBL220357 1 7.16
CHEMBL374936 1 6.91
CHEMBL374703 1 6.80
CHEMBL219602 1 6.72
CHEMBL438992 1 6.70
CHEMBL218882 1 6.48
CHEMBL218911 1 6.28
CHEMBL220402 1 6.25
CHEMBL216855 1 6.08
CHEMBL375414 1 6.00
CHEMBL220404 1 5.92
CHEMBL220301 1 5.79
CHEMBL220249 1 5.75
CHEMBL218254 1 5.74
CHEMBL216774 1 5.74
CHEMBL218306 1 5.52
CHEMBL220021 1 5.42
CHEMBL374032 1 5.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL386812 IC50 = 8.0 nM 8.10
CHEMBL376498 IC50 = 13.0 nM 7.89
CHEMBL219371 IC50 = 13.0 nM 7.89
CHEMBL216835 IC50 = 17.0 nM 7.77
CHEMBL375745 IC50 = 19.0 nM 7.72
CHEMBL387333 IC50 = 19.0 nM 7.72
CHEMBL218776 IC50 = 19.0 nM 7.72
CHEMBL375146 IC50 = 19.0 nM 7.72
CHEMBL219434 IC50 = 31.0 nM 7.51
CHEMBL435320 IC50 = 40.0 nM 7.40
CHEMBL219278 IC50 = 43.0 nM 7.37
CHEMBL375442 IC50 = 52.0 nM 7.28
CHEMBL220357 IC50 = 70.0 nM 7.16
CHEMBL374936 IC50 = 122.0 nM 6.91
CHEMBL374703 IC50 = 160.0 nM 6.80
CHEMBL219602 IC50 = 190.0 nM 6.72
CHEMBL438992 IC50 = 200.0 nM 6.70
CHEMBL218882 IC50 = 330.0 nM 6.48
CHEMBL218911 IC50 = 520.0 nM 6.28
CHEMBL220402 IC50 = 560.0 nM 6.25
CHEMBL216855 IC50 = 830.0 nM 6.08
CHEMBL375414 IC50 = 990.0 nM 6.00
CHEMBL220404 IC50 = 1210.0 nM 5.92
CHEMBL220301 IC50 = 1610.0 nM 5.79
CHEMBL220249 IC50 = 1790.0 nM 5.75
CHEMBL218254 IC50 = 1830.0 nM 5.74
CHEMBL216774 IC50 = 1820.0 nM 5.74
CHEMBL218306 IC50 = 3050.0 nM 5.52
CHEMBL220021 IC50 = 3820.0 nM 5.42
CHEMBL374032 IC50 = 4590.0 nM 5.34
CHEMBL219369 IC50 = 4790.0 nM 5.32
CHEMBL219370 IC50 = 4820.0 nM 5.32
CHEMBL219382 IC50 = 7360.0 nM 5.13
CHEMBL426335 IC50 = 12400.0 nM 4.91
CHEMBL375875 IC50 = 15600.0 nM 4.81
CHEMBL216854 IC50 = 19700.0 nM 4.71