Assay Detail
Functional
CHEMBL856542
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Antiproliferative activity against LT12 MDR cells by XTT assay after 48 hrs
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | MDR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.73 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | 7.16 |
| CHEMBL219102 | — | — | 1 | 6.77 |
| CHEMBL219439 | — | — | 1 | 6.72 |
| CHEMBL238071 | VINDESINE | 3.0 | 1 | 6.58 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9514 | NOCODAZOLE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL219102 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL219439 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL238071 | VINDESINE | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 400.0 | nM | 6.40 |