Assay Detail
Binding
CHEMBL856601
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Equilibrium dissociation constant determined against human purine nucleoside phosphorylase (PNP) after slow-onset inhibition
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 9.59 | 10.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473922 | — | — | 1 | 10.38 |
| CHEMBL218291 | FORODESINE | 4.0 | 1 | 10.25 |
| CHEMBL2311112 | — | — | 1 | 9.74 |
| CHEMBL542455 | — | — | 1 | 9.41 |
| CHEMBL117383 | — | — | 1 | 8.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473922 | — | Ki | = | 0.042 | nM | 10.38 |
| CHEMBL218291 | FORODESINE | Ki | = | 0.056 | nM | 10.25 |
| CHEMBL2311112 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL542455 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL117383 | — | Ki | = | 7.0 | nM | 8.15 |