Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL856674

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibitory activity against Plasmodium falciparum D6
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Hydroxy-anthraquinones as antimalarial agents
Winter R, Cornell KA, Johnson LL, Isabelle LM, Hinrichs DJ, Riscoe MK
Bioorg Med Chem Lett (1995) 5 : 1927 -1932
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.40 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL76 CHLOROQUINE 4.0 1 7.70
CHEMBL58972 1 7.46
CHEMBL58967 1 6.52
CHEMBL293801 1 6.10
CHEMBL57998 1 5.30
CHEMBL55659 ANTHRAQUINONE 1 5.30
CHEMBL294264 PURPURIN 1 -
CHEMBL298398 ANTHRAFLAVICACID 1 -
CHEMBL278445 1 -
CHEMBL55761 ANTHRARUFIN 1 -
CHEMBL58573 1 -
CHEMBL412657 1 -
CHEMBL418453 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL76 CHLOROQUINE IC50 = 20.0 nM 7.70
CHEMBL58972 IC50 = 35.0 nM 7.46
CHEMBL58967 IC50 = 300.0 nM 6.52
CHEMBL293801 IC50 = 800.0 nM 6.10
CHEMBL57998 IC50 = 5000.0 nM 5.30
CHEMBL55659 ANTHRAQUINONE IC50 = 5000.0 nM 5.30
CHEMBL294264 PURPURIN IC50 > 1000.0 nM -
CHEMBL298398 ANTHRAFLAVICACID IC50 > 1000.0 nM -
CHEMBL278445 IC50 >= 5000.0 nM -
CHEMBL55761 ANTHRARUFIN IC50 > 1000.0 nM -
CHEMBL58573 IC50 >= 5000.0 nM -
CHEMBL412657 IC50 >= 5000.0 nM -
CHEMBL418453 IC50 >= 5000.0 nM -