Assay Detail
Functional
CHEMBL856713
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of daunorubicin resistance in P388 ADR cells by MTS assay at 5 uM
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388/ADR |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Flavonoid dimers as bivalent modulators for P-glycoprotein-based multidrug resistance: synthetic apigenin homodimers linked with defined-length poly(ethylene glycol) spacers increase drug retention and enhance chemosensitivity in resistant cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.00 | 7.00 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214738 | — | — | 1 | 7.00 |
| CHEMBL215017 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214738 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL215017 | — | Activity | - | — | - |