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Assay Detail

CHEMBL856755

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
The compound was estimated for biosensor analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Biosensor analysis of the interaction between immobilized human serum albumin and drug compounds for prediction of human serum albumin binding levels.
Frostell-Karlsson A, Remaeus A, Roos H, Andersson K, Borg P, Hämäläinen M, Karlsson R.
J Med Chem (2000) 43 : 1986 -1992
PubMed 10821711 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 6 4.72 5.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1464 WARFARIN 4.0 1 5.05
CHEMBL163 RITONAVIR 4.0 1 4.68
CHEMBL154 NAPROXEN 4.0 1 4.58
CHEMBL254219 DIGITOXIN 4.0 1 4.55
CHEMBL374478 RIFAMPIN 4.0 1 -
CHEMBL170 QUININE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1464 WARFARIN Kd = 9000.0 nM 5.05
CHEMBL163 RITONAVIR Kd = 21000.0 nM 4.68
CHEMBL154 NAPROXEN Kd = 26000.0 nM 4.58
CHEMBL254219 DIGITOXIN Kd = 28000.0 nM 4.55
CHEMBL374478 RIFAMPIN Kd = 195000.0 nM -
CHEMBL170 QUININE Kd = 556000.0 nM -