Assay Detail
Binding
CHEMBL856757
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Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type A receptor in pancreatic membranes of guinea-pig
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-based design and pharmacological properties of potent selective and systemically active CCK-B peptidomimetics
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.72 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 9.19 |
| CHEMBL262894 | — | — | 1 | 7.21 |
| CHEMBL428666 | — | — | 1 | 7.11 |
| CHEMBL436722 | — | — | 1 | 6.00 |
| CHEMBL412917 | — | — | 1 | 5.96 |
| CHEMBL353862 | — | — | 1 | 5.96 |
| CHEMBL171594 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL262894 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL428666 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL436722 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL412917 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL353862 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL171594 | — | Ki | = | 2400.0 | nM | 5.62 |