Assay Detail
Binding
CHEMBL856870
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human BACE1 by MBPC125Swe assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PC-12 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and crystal structure of hydroxyethyl secondary amine-based peptidomimetic inhibitors of human beta-secretase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.13 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373533 | — | — | 1 | 8.30 |
| CHEMBL221597 | — | — | 1 | 7.70 |
| CHEMBL265861 | — | — | 1 | 7.16 |
| CHEMBL375540 | — | — | 1 | 6.89 |
| CHEMBL221086 | — | — | 1 | 6.89 |
| CHEMBL265862 | — | — | 1 | 6.70 |
| CHEMBL220813 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373533 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL221597 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL265861 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL375540 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL221086 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL265862 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL220813 | — | IC50 | = | 500.0 | nM | 6.30 |