Assay Detail
Functional
CHEMBL856871
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of beta amyloid production in human HEK293 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
Design, synthesis, and crystal structure of hydroxyethyl secondary amine-based peptidomimetic inhibitors of human beta-secretase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.19 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373533 | — | — | 1 | 8.52 |
| CHEMBL221597 | — | — | 1 | 7.82 |
| CHEMBL221086 | — | — | 1 | 7.40 |
| CHEMBL265861 | — | — | 1 | 7.10 |
| CHEMBL375540 | — | — | 1 | 6.64 |
| CHEMBL265862 | — | — | 1 | 6.64 |
| CHEMBL220813 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373533 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL221597 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL221086 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL265861 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL375540 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL265862 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL220813 | — | EC50 | = | 600.0 | nM | 6.22 |