Assay Detail
Binding
CHEMBL857068
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Binding affinity towards 5-hydroxytryptamine 1B receptor by displacement of [3H]5-HT.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis, biological activity and quantitative structure-activity relationships of N-substituted-3,4-dihydro-2H-1-benzopyran derivatives
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.18 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11409 | — | — | 1 | 5.80 |
| CHEMBL416523 | — | — | 1 | 5.52 |
| CHEMBL11265 | — | — | 1 | 5.42 |
| CHEMBL11592 | — | — | 1 | 5.30 |
| CHEMBL11425 | — | — | 1 | 5.16 |
| CHEMBL417608 | — | — | 1 | 5.13 |
| CHEMBL11262 | — | — | 1 | 4.64 |
| CHEMBL275481 | — | — | 1 | 4.45 |
| CHEMBL416336 | — | — | 1 | - |
| CHEMBL438755 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11409 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL416523 | — | IC50 | = | 3019.95 | nM | 5.52 |
| CHEMBL11265 | — | IC50 | = | 3801.89 | nM | 5.42 |
| CHEMBL11592 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL11425 | — | IC50 | = | 6918.31 | nM | 5.16 |
| CHEMBL417608 | — | IC50 | = | 7413.1 | nM | 5.13 |
| CHEMBL11262 | — | IC50 | = | 22908.68 | nM | 4.64 |
| CHEMBL275481 | — | IC50 | = | 35481.34 | nM | 4.45 |
| CHEMBL416336 | — | IC50 | = | 138038.43 | nM | - |
| CHEMBL438755 | — | IC50 | < | 100000.0 | nM | - |