Assay Detail
Binding
CHEMBL857078
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In vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblasts
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2-(anilinomethyl)imidazolines as alpha1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.93 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL155327 | — | — | 1 | 7.42 |
| CHEMBL155326 | — | — | 1 | 7.39 |
| CHEMBL351542 | — | — | 1 | 7.37 |
| CHEMBL154298 | — | — | 1 | 6.93 |
| CHEMBL117381 | — | — | 1 | 6.53 |
| CHEMBL154023 | — | — | 1 | 6.46 |
| CHEMBL156661 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL155327 | — | IC50 | = | 38.02 | nM | 7.42 |
| CHEMBL155326 | — | IC50 | = | 40.74 | nM | 7.39 |
| CHEMBL351542 | — | IC50 | = | 42.66 | nM | 7.37 |
| CHEMBL154298 | — | IC50 | = | 117.49 | nM | 6.93 |
| CHEMBL117381 | — | IC50 | = | 295.12 | nM | 6.53 |
| CHEMBL154023 | — | IC50 | = | 346.74 | nM | 6.46 |
| CHEMBL156661 | — | IC50 | = | 416.87 | nM | 6.38 |