Assay Detail
Functional
CHEMBL857121
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H1-antihistamine activity in guinea pig ileum
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Studies on 1,2,3-triazoles. 13. (Piperazinylalkoxy) [1]benzopyrano[2,3-d]-1,2,3-triazol-9(1H)-ones with combined H1-antihistamine and mast cell stabilizing properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 8.73 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL534 | KETOTIFEN | 4.0 | 1 | 9.50 |
| CHEMBL74870 | — | — | 1 | 9.10 |
| CHEMBL511 | PYRILAMINE | 4.0 | 1 | 9.10 |
| CHEMBL308791 | — | — | 1 | 8.80 |
| CHEMBL420934 | — | — | 1 | 8.40 |
| CHEMBL74989 | — | — | 1 | 8.40 |
| CHEMBL420567 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL534 | KETOTIFEN | Kd | = | 0.3162 | nM | 9.50 |
| CHEMBL74870 | — | Kd | = | 0.7943 | nM | 9.10 |
| CHEMBL511 | PYRILAMINE | Kd | = | 0.7943 | nM | 9.10 |
| CHEMBL308791 | — | Kd | = | 1.585 | nM | 8.80 |
| CHEMBL420934 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL74989 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL420567 | — | Kd | = | 15.85 | nM | 7.80 |