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Assay Detail

CHEMBL857141

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Oryctolagus cuniculus
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Substance-K receptor (CHEMBL3433)
Type SINGLE PROTEIN
Organism Oryctolagus cuniculus

Publication

Influence of lipophilicity on the biological activity of cyclic pseudopeptide NK-2 receptor antagonists.
Quartara L, Fabbri G, Ricci R, Patacchini R, Pestellini V, Maggi CA, Pavone V, Giachetti A, Arcamone F.
J Med Chem (1994) 37 : 3630 -3638
PubMed 7932590 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 13 6.69 7.81

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL334186 1 7.81
CHEMBL121271 1 7.37
CHEMBL331480 1 7.27
CHEMBL330810 1 7.10
CHEMBL421062 1 6.95
CHEMBL333515 1 6.93
CHEMBL333027 1 6.89
CHEMBL427606 1 6.89
CHEMBL121571 1 6.65
CHEMBL433192 1 6.16
CHEMBL332872 1 5.97
CHEMBL421071 1 5.84
CHEMBL384610 1 5.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL334186 Kd = 15.49 nM 7.81
CHEMBL121271 Kd = 42.66 nM 7.37
CHEMBL331480 Kd = 53.7 nM 7.27
CHEMBL330810 Kd = 79.43 nM 7.10
CHEMBL421062 Kd = 112.2 nM 6.95
CHEMBL333515 Kd = 117.49 nM 6.93
CHEMBL333027 Kd = 128.82 nM 6.89
CHEMBL427606 Kd = 128.82 nM 6.89
CHEMBL121571 Kd = 223.87 nM 6.65
CHEMBL433192 Kd = 691.83 nM 6.16
CHEMBL332872 Kd = 1071.52 nM 5.97
CHEMBL421071 Kd = 1445.44 nM 5.84
CHEMBL384610 Kd = 7943.28 nM 5.10