Assay Detail
Functional
CHEMBL857168
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Negative logarithm of growth inhibitory concentration (IC50) against human colon adenocarcinoma cell line (HT-29)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, biological activity, and quantitative structure-activity relationship study of azanaphthalimide and arylnaphthalimide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.69 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74167 | — | — | 1 | 7.68 |
| CHEMBL73034 | — | — | 1 | 6.80 |
| CHEMBL432721 | — | — | 1 | 5.92 |
| CHEMBL308527 | — | — | 1 | 5.46 |
| CHEMBL304619 | — | — | 1 | 5.44 |
| CHEMBL70270 | — | — | 1 | 5.32 |
| CHEMBL70612 | — | — | 1 | 5.25 |
| CHEMBL308603 | — | — | 1 | 5.24 |
| CHEMBL307755 | — | — | 1 | 4.93 |
| CHEMBL308697 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74167 | — | IC50 | = | 20.89 | nM | 7.68 |
| CHEMBL73034 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL432721 | — | IC50 | = | 1202.26 | nM | 5.92 |
| CHEMBL308527 | — | IC50 | = | 3467.37 | nM | 5.46 |
| CHEMBL304619 | — | IC50 | = | 3630.78 | nM | 5.44 |
| CHEMBL70270 | — | IC50 | = | 4786.3 | nM | 5.32 |
| CHEMBL70612 | — | IC50 | = | 5623.41 | nM | 5.25 |
| CHEMBL308603 | — | IC50 | = | 5754.4 | nM | 5.24 |
| CHEMBL307755 | — | IC50 | = | 11748.98 | nM | 4.93 |
| CHEMBL308697 | — | IC50 | = | 15135.61 | nM | 4.82 |