Assay Detail
Functional
CHEMBL857326
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist selectivity for orexin receptor 1 versus orexin receptor 2
63
Total Activities
61
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Development of an orexin-2 receptor selective agonist, [Ala(11), D-Leu(15)]orexin-B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 60 | 7.94 | 8.64 |
| selectivity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265504 | — | — | 1 | 8.64 |
| CHEMBL386549 | — | — | 1 | 8.62 |
| CHEMBL439541 | — | — | 1 | 8.49 |
| CHEMBL440060 | — | — | 1 | 8.42 |
| CHEMBL436915 | — | — | 1 | 8.35 |
| CHEMBL409968 | — | — | 1 | 8.29 |
| CHEMBL410899 | — | — | 1 | 8.28 |
| CHEMBL265907 | — | — | 1 | 8.26 |
| CHEMBL410947 | — | — | 1 | 8.24 |
| CHEMBL441008 | — | — | 1 | 8.23 |
| CHEMBL264482 | — | — | 1 | 8.22 |
| CHEMBL428123 | — | — | 1 | 8.17 |
| CHEMBL430313 | — | — | 1 | 8.16 |
| CHEMBL264342 | — | — | 1 | 8.15 |
| CHEMBL413884 | — | — | 1 | 8.10 |
| CHEMBL410816 | — | — | 1 | 8.09 |
| CHEMBL265746 | — | — | 1 | 8.08 |
| CHEMBL265423 | — | — | 1 | 8.08 |
| CHEMBL439288 | — | — | 1 | 8.08 |
| CHEMBL427771 | — | — | 1 | 8.04 |
| CHEMBL411174 | — | — | 1 | 8.03 |
| CHEMBL409301 | — | — | 1 | 8.00 |
| CHEMBL409970 | — | — | 1 | 8.00 |
| CHEMBL413434 | OREXIN B | — | 3 | 8.00 |
| CHEMBL410960 | — | — | 1 | 7.96 |
| CHEMBL442505 | — | — | 1 | 7.96 |
| CHEMBL414332 | — | — | 1 | 7.96 |
| CHEMBL410898 | — | — | 1 | 7.96 |
| CHEMBL264343 | — | — | 1 | 7.92 |
| CHEMBL409456 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265504 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL386549 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL439541 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL440060 | — | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL436915 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL409968 | — | EC50 | = | 5.1 | nM | 8.29 |
| CHEMBL410899 | — | EC50 | = | 5.3 | nM | 8.28 |
| CHEMBL265907 | — | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL410947 | — | EC50 | = | 5.8 | nM | 8.24 |
| CHEMBL441008 | — | EC50 | = | 5.9 | nM | 8.23 |
| CHEMBL264482 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL428123 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL430313 | — | EC50 | = | 6.9 | nM | 8.16 |
| CHEMBL264342 | — | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL413884 | — | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL410816 | — | EC50 | = | 8.2 | nM | 8.09 |
| CHEMBL265746 | — | EC50 | = | 8.3 | nM | 8.08 |
| CHEMBL439288 | — | EC50 | = | 8.3 | nM | 8.08 |
| CHEMBL265423 | — | EC50 | = | 8.4 | nM | 8.08 |
| CHEMBL427771 | — | EC50 | = | 9.2 | nM | 8.04 |
| CHEMBL411174 | — | EC50 | = | 9.4 | nM | 8.03 |
| CHEMBL413434 | OREXIN B | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL413434 | OREXIN B | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL409301 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL409970 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL410960 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL414332 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL410898 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL442505 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL264343 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL409456 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL414312 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL430064 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL437464 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL413504 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL265404 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL263628 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL413284 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL413285 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL437274 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL410480 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL409676 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL430080 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL266409 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL438036 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL269780 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL411116 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL442503 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL409967 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL275985 | — | EC50 | = | 28.0 | nM | 7.55 |