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Assay Detail

CHEMBL857385

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Functional
Inhibitory concentration against friend cells proliferation
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type Friend leukemia cell line
Confidence 1 — Organism
Curated By Expert

Publication

Histone deacetylase inhibitors.
Miller TA, Witter DJ, Belvedere S.
J Med Chem (2003) 46 : 5097 -5116
PubMed 14613312 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 4.86 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL99 TRICHOSTATIN 1.0 1 7.40
CHEMBL98 VORINOSTAT 4.0 1 6.00
CHEMBL113337 1 5.28
CHEMBL264629 1 4.89
CHEMBL46941 1 4.82
CHEMBL110906 1 4.82
CHEMBL111993 1 4.82
CHEMBL331150 1 4.66
CHEMBL109960 1 4.55
CHEMBL419029 1 4.24
CHEMBL326022 1 4.19
CHEMBL113095 1 4.16
CHEMBL320038 1 4.14
CHEMBL111919 1 4.12

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL99 TRICHOSTATIN IC50 = 40.0 nM 7.40
CHEMBL98 VORINOSTAT IC50 = 990.0 nM 6.00
CHEMBL113337 IC50 = 5200.0 nM 5.28
CHEMBL264629 IC50 = 13000.0 nM 4.89
CHEMBL46941 IC50 = 15000.0 nM 4.82
CHEMBL110906 IC50 = 15000.0 nM 4.82
CHEMBL111993 IC50 = 15000.0 nM 4.82
CHEMBL331150 IC50 = 22000.0 nM 4.66
CHEMBL109960 IC50 = 28000.0 nM 4.55
CHEMBL419029 IC50 = 58000.0 nM 4.24
CHEMBL326022 IC50 = 64000.0 nM 4.19
CHEMBL113095 IC50 = 69000.0 nM 4.16
CHEMBL320038 IC50 = 72000.0 nM 4.14
CHEMBL111919 IC50 = 76000.0 nM 4.12