Assay Detail
Binding
CHEMBL857421
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of c-Raf1 kinase
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
RAF proto-oncogene serine/threonine-protein kinase (CHEMBL1906) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.42 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1880739 | GW305074X | — | 1 | 7.96 |
| CHEMBL176857 | GW442130X | — | 1 | 6.16 |
| CHEMBL172179 | — | — | 1 | 5.14 |
| CHEMBL176544 | — | — | 1 | - |
| CHEMBL1794059 | GW275616X | — | 1 | - |
| CHEMBL175321 | — | — | 1 | - |
| CHEMBL1794057 | GW284408X | — | 1 | - |
| CHEMBL1794056 | GW301789X | — | 1 | - |
| CHEMBL369490 | — | — | 1 | - |
| CHEMBL1794058 | GW278681X | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1880739 | GW305074X | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL176857 | GW442130X | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL172179 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL176544 | — | IC50 | > | 12000.0 | nM | - |
| CHEMBL1794059 | GW275616X | IC50 | > | 10000.0 | nM | - |
| CHEMBL175321 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1794057 | GW284408X | IC50 | > | 10000.0 | nM | - |
| CHEMBL1794056 | GW301789X | IC50 | > | 10000.0 | nM | - |
| CHEMBL369490 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1794058 | GW278681X | IC50 | > | 10000.0 | nM | - |