Assay Detail
Binding
CHEMBL857529
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Inhibition of type-1 human steroid 5-alpha-reductase
17
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (CHEMBL1787) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A comparison of steroidal and non-steroidal inhibitors of human steroid 5-reductase: New tricyclic aryl acid inhibitors of the type-1 isozyme
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.67 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2298601 | — | — | 1 | 8.52 |
| CHEMBL29166 | — | — | 2 | 8.05 |
| CHEMBL420020 | — | — | 1 | 8.05 |
| CHEMBL25578 | — | — | 1 | 7.58 |
| CHEMBL341625 | — | — | 1 | 6.50 |
| CHEMBL356780 | — | — | 1 | 6.50 |
| CHEMBL138225 | EPRISTERIDE | 2.0 | 1 | 6.39 |
| CHEMBL76192 | — | — | 1 | 6.09 |
| CHEMBL97266 | — | — | 1 | 6.04 |
| CHEMBL25081 | — | — | 1 | 5.92 |
| CHEMBL1627951 | — | — | 1 | 5.80 |
| CHEMBL439804 | — | — | 1 | 5.72 |
| CHEMBL143220 | — | — | 1 | 5.50 |
| CHEMBL110001 | — | — | 1 | 5.38 |
| CHEMBL144346 | — | — | 1 | - |
| CHEMBL341666 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2298601 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL420020 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL29166 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL29166 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL25578 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL356780 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL341625 | — | Ki | = | 315.0 | nM | 6.50 |
| CHEMBL138225 | EPRISTERIDE | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL76192 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL97266 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL25081 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL1627951 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL439804 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL143220 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL110001 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL144346 | — | Ki | > | 2500.0 | nM | - |
| CHEMBL341666 | — | Ki | > | 2500.0 | nM | - |