Assay Detail
Binding
CHEMBL857542
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Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | IM-9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Aza-tricyclic substance P antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.55 | 9.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | — | 1 | 9.32 |
| CHEMBL329090 | — | — | 1 | 9.04 |
| CHEMBL97241 | — | — | 1 | 8.72 |
| CHEMBL95561 | — | — | 1 | 8.62 |
| CHEMBL317761 | — | — | 1 | 8.48 |
| CHEMBL442962 | — | — | 1 | 8.39 |
| CHEMBL319559 | — | — | 1 | 8.15 |
| CHEMBL317297 | — | — | 1 | 8.14 |
| CHEMBL313863 | — | — | 1 | 7.41 |
| CHEMBL95270 | — | — | 1 | 7.24 |
| CHEMBL316842 | — | — | 1 | 7.17 |
| CHEMBL330362 | — | — | 1 | 6.77 |
| CHEMBL317289 | — | — | 1 | 6.64 |
| CHEMBL96956 | — | — | 1 | 5.96 |
| CHEMBL327943 | — | — | 1 | 5.36 |
| CHEMBL318629 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL329090 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL97241 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL95561 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL317761 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL442962 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL319559 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL317297 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL313863 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL95270 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL316842 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL330362 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL317289 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL96956 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL327943 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL318629 | — | IC50 | = | 4800.0 | nM | 5.32 |