Assay Detail
Binding
CHEMBL857544
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Inhibition of [3H]Ro-256981 binding to N-methyl-D-aspartate glutamate receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.47 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219631 | BESONPRODIL | -1.0 | 1 | 8.40 |
| CHEMBL305195 | — | — | 1 | 8.22 |
| CHEMBL126929 | — | — | 1 | 8.22 |
| CHEMBL333936 | — | — | 1 | 7.92 |
| CHEMBL124873 | — | — | 1 | 7.75 |
| CHEMBL127510 | — | — | 1 | 7.72 |
| CHEMBL126228 | — | — | 1 | 7.51 |
| CHEMBL419784 | — | — | 1 | 7.33 |
| CHEMBL124516 | — | — | 1 | 6.97 |
| CHEMBL113919 | — | — | 1 | 6.71 |
| CHEMBL339570 | — | — | 1 | 6.45 |
| CHEMBL123908 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219631 | BESONPRODIL | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL305195 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL126929 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL333936 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL124873 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL127510 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL126228 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL419784 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL124516 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL113919 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL339570 | — | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL123908 | — | IC50 | = | 380.0 | nM | 6.42 |