Assay Detail
Binding
CHEMBL857545
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration required to inhibit [3H]strychnine binding to N-methyl-D-aspartate glutamate receptor 1 of rat spinal cord membranes.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 1 (CHEMBL330) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Beta-proline analogues as agonists at the strychnine-sensitive glycine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.49 | 4.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297569 | BETA-ALANINE | — | 1 | 4.94 |
| CHEMBL66693 | D-ALANINE | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297569 | BETA-ALANINE | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL66693 | D-ALANINE | IC50 | = | 90900.0 | nM | 4.04 |