Assay Detail
Binding
CHEMBL857548
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibition of NK1 receptor from gerbil midbrain
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gerbillinae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
SAR of 2-benzyl-4-aminopiperidines: CGP 49823, an orally and centrally active non-peptide NK1 antagonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.98 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43912 | — | — | 1 | 7.32 |
| CHEMBL290364 | — | — | 1 | 7.26 |
| CHEMBL295122 | — | — | 1 | 7.16 |
| CHEMBL297883 | — | — | 1 | 6.16 |
| CHEMBL295425 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43912 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL290364 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL295122 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL297883 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL295425 | — | IC50 | = | 10.0 | — | - |