Assay Detail
Binding
CHEMBL857568
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Inhibition of partially-purified PDE 4 from human monocytes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
The crystal structure, absolute configuration, and phosphodiesterase inhibitory activity of (+)-1-(4-bromobenzyl)-4-(3-(cyclopentyloxy)- 4-methoxyphenyl)-pyrrolidin-2-one.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.14 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109965 | — | — | 1 | 6.77 |
| CHEMBL326068 | — | — | 1 | 6.13 |
| CHEMBL430893 | (-)-ROLIPRAM | — | 1 | 5.85 |
| CHEMBL325795 | S-ROLIPRAM | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109965 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL326068 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL430893 | (-)-ROLIPRAM | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL325795 | S-ROLIPRAM | IC50 | = | 1600.0 | nM | 5.80 |