Assay Detail
Binding
CHEMBL857594
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to FK506 binding protein 12 was determined
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Peptidyl-prolyl cis-trans isomerase FKBP1A (CHEMBL1902) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of FK506-Cyclosporin hybrid macrocycles
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 7.18 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269732 | TACROLIMUS ANHYDROUS | 4.0 | 1 | 9.70 |
| CHEMBL77154 | — | — | 1 | 7.05 |
| CHEMBL421507 | — | — | 1 | 6.50 |
| CHEMBL407550 | — | — | 1 | 6.46 |
| CHEMBL430805 | — | — | 1 | 6.19 |
| CHEMBL306125 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269732 | TACROLIMUS ANHYDROUS | Kd | = | 0.2 | nM | 9.70 |
| CHEMBL77154 | — | Kd | = | 90.0 | nM | 7.05 |
| CHEMBL421507 | — | Kd | = | 320.0 | nM | 6.50 |
| CHEMBL407550 | — | Kd | = | 344.0 | nM | 6.46 |
| CHEMBL430805 | — | Kd | = | 644.0 | nM | 6.19 |
| CHEMBL306125 | — | Kd | > | 1000.0 | nM | - |