Assay Detail
Binding
CHEMBL857631
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Inhibitory activity against histone deacetylase (HDAC) enzyme derived from partially purified extracts of human HeLa cells using [3H]11 as radioligand
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.71 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1793991 | — | — | 1 | 9.70 |
| CHEMBL1793985 | — | — | 1 | 9.70 |
| CHEMBL430060 | APICIDIN | — | 1 | 9.00 |
| CHEMBL1793992 | — | — | 1 | 8.89 |
| CHEMBL1793989 | — | — | 1 | 8.70 |
| CHEMBL1793984 | — | — | 1 | 8.40 |
| CHEMBL1793982 | — | — | 1 | 7.89 |
| CHEMBL1793990 | — | — | 1 | 7.82 |
| CHEMBL1793974 | — | — | 1 | 7.47 |
| CHEMBL1793983 | — | — | 1 | 7.17 |
| CHEMBL1793973 | — | — | 1 | 7.07 |
| CHEMBL1793968 | — | — | 1 | 7.04 |
| CHEMBL1793969 | — | — | 1 | 6.59 |
| CHEMBL1793972 | — | — | 1 | 6.48 |
| CHEMBL1793978 | — | — | 1 | 6.38 |
| CHEMBL279636 | — | — | 1 | 6.37 |
| CHEMBL1793981 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1793991 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1793985 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL430060 | APICIDIN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1793992 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL1793989 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1793984 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1793982 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1793990 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1793974 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1793983 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1793973 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL1793968 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL1793969 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL1793972 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1793978 | — | IC50 | = | 419.0 | nM | 6.38 |
| CHEMBL279636 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1793981 | — | IC50 | = | 444.0 | nM | 6.35 |