Assay Detail
Binding
CHEMBL857699
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Inhibitory concentration required for in vitro binding affinity to Nicotinic acetylcholine receptor alpha4-beta2 expressed on cell line sf 21 by using [3H]-MCC
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of novel (isoxazole)methylene-1-azabicyclic compounds with high affinity for the central nicotinic cholinergic receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.97 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58416 | — | — | 1 | 8.85 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 8.38 |
| CHEMBL291442 | — | — | 1 | 8.19 |
| CHEMBL60656 | — | — | 1 | 7.58 |
| CHEMBL274525 | ABT-418 | — | 1 | 7.43 |
| CHEMBL144540 | — | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58416 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3 | NICOTINE | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL291442 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL60656 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL274525 | ABT-418 | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL144540 | — | IC50 | = | 41.0 | nM | 7.39 |