Assay Detail
Functional
CHEMBL857764
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration of [3H]- nitrendipine binding against guinea pig cerebral cortex membrane
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cerebral cortex |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel heterocyclic analogues of the new potent class of calcium entry blockers: 1-[[4-(aminoalkoxy)phenyl]sulfonyl]indolizines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 8.28 | 10.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33620 | — | — | 1 | 10.14 |
| CHEMBL34509 | — | — | 1 | 10.03 |
| CHEMBL32989 | — | — | 1 | 9.66 |
| CHEMBL34685 | — | — | 1 | 9.55 |
| CHEMBL33344 | — | — | 1 | 9.23 |
| CHEMBL285855 | FANTOFARONE | 2.0 | 1 | 9.21 |
| CHEMBL34058 | — | — | 1 | 9.19 |
| CHEMBL31082 | — | — | 1 | 9.00 |
| CHEMBL30440 | — | — | 1 | 9.00 |
| CHEMBL287679 | — | — | 1 | 8.96 |
| CHEMBL33001 | — | — | 1 | 8.80 |
| CHEMBL33326 | — | — | 1 | 8.72 |
| CHEMBL34450 | — | — | 1 | 8.66 |
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 8.60 |
| CHEMBL33293 | — | — | 1 | 8.59 |
| CHEMBL417136 | — | — | 1 | 8.28 |
| CHEMBL34100 | — | — | 1 | 8.14 |
| CHEMBL33559 | — | — | 1 | 8.10 |
| CHEMBL33072 | — | — | 1 | 7.96 |
| CHEMBL30535 | — | — | 1 | 7.96 |
| CHEMBL33560 | — | — | 1 | 7.92 |
| CHEMBL30321 | — | — | 1 | 7.88 |
| CHEMBL33738 | — | — | 1 | 7.87 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 7.42 |
| CHEMBL33735 | — | — | 1 | 7.03 |
| CHEMBL281749 | — | — | 1 | 6.96 |
| CHEMBL418045 | — | — | 1 | 6.94 |
| CHEMBL33497 | — | — | 1 | 6.82 |
| CHEMBL33531 | — | — | 1 | 6.74 |
| CHEMBL33740 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33620 | — | IC50 | = | 0.072 | nM | 10.14 |
| CHEMBL34509 | — | IC50 | = | 0.093 | nM | 10.03 |
| CHEMBL32989 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL34685 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL33344 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL285855 | FANTOFARONE | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL34058 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL31082 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL30440 | — | IC50 | = | 0.99 | nM | 9.00 |
| CHEMBL287679 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL33001 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL33326 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL34450 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL193 | NIFEDIPINE | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL33293 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL417136 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL34100 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL33559 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL33072 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL30535 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL33560 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL30321 | — | IC50 | = | 13.1 | nM | 7.88 |
| CHEMBL33738 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL33735 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL281749 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL418045 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL33497 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL33531 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL33740 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL30954 | — | IC50 | = | 244.0 | nM | 6.61 |