Assay Detail
Binding
CHEMBL857782
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Binding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brain
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
1,5-Benzodiazepines as CCK-B antagonists. Effect of halogen substitution at the benzo-fused ring on potency and selectivity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.20 | 6.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319795 | — | — | 1 | 6.65 |
| CHEMBL103750 | — | — | 1 | 6.49 |
| CHEMBL101125 | — | — | 1 | 6.02 |
| CHEMBL103968 | — | — | 1 | 6.02 |
| CHEMBL102867 | — | — | 1 | 5.80 |
| CHEMBL317081 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319795 | — | Ki | = | 223.87 | nM | 6.65 |
| CHEMBL103750 | — | Ki | = | 323.59 | nM | 6.49 |
| CHEMBL101125 | — | Ki | = | 954.99 | nM | 6.02 |
| CHEMBL103968 | — | Ki | = | 954.99 | nM | 6.02 |
| CHEMBL102867 | — | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL317081 | — | Ki | < | 1000.0 | nM | - |