Assay Detail
Binding
CHEMBL857982
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against human 5-hydroxytryptamine 2C receptor expressed in 293 cells using [3H]mesulergine
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole: a novel 5-HT2C/5-HT2B receptor antagonist with improved affinity, selectivity, and oral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.86 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297784 | — | — | 1 | 8.00 |
| CHEMBL315223 | — | — | 1 | 7.18 |
| CHEMBL84888 | — | — | 1 | 5.39 |
| CHEMBL85247 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297784 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL315223 | — | Ki | = | 66.07 | nM | 7.18 |
| CHEMBL84888 | — | Ki | = | 4073.8 | nM | 5.39 |
| CHEMBL85247 | — | Ki | < | 6309.57 | nM | - |