Assay Detail
Functional
CHEMBL858102
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to cause cAMP accumulation in CHO cells expressing human beta-3 AR expressed as the negative logarithm of the molar drug concentration
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of potent and selective beta(3) adrenergic receptor agonists containing acylsulfonamide, sulfonylsulfonamide, and sulfonylurea carboxylic acid isosteres.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.68 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422876 | — | — | 1 | 8.00 |
| CHEMBL154906 | — | — | 1 | 7.80 |
| CHEMBL348269 | — | — | 1 | 7.70 |
| CHEMBL154370 | — | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422876 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL154906 | — | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL348269 | — | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL154370 | — | EC50 | = | 63.1 | nM | 7.20 |