Assay Detail
Binding
CHEMBL858266
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition constant against Bacillus subtilis azp-12 DNA topoisomerase III (mutant enzyme).
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus subtilis |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
DNA topoisomerase 3 (CHEMBL4320) ↗| Type | SINGLE PROTEIN |
| Organism | Bacillus subtilis (strain 168) |
Publication
Quantitative structure-activity relationships of 6-anilinouracils as inhibitors of Bacillus subtilis DNA polymerase III.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 5.25 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55032 | — | — | 1 | 6.82 |
| CHEMBL56014 | — | — | 1 | 6.55 |
| CHEMBL52034 | — | — | 1 | 6.48 |
| CHEMBL55145 | — | — | 1 | 6.08 |
| CHEMBL53413 | — | — | 1 | 6.07 |
| CHEMBL53002 | — | — | 1 | 5.85 |
| CHEMBL54950 | — | — | 1 | 5.71 |
| CHEMBL54782 | — | — | 1 | 5.46 |
| CHEMBL293964 | — | — | 1 | 5.40 |
| CHEMBL54371 | — | — | 1 | 5.38 |
| CHEMBL441976 | — | — | 1 | 5.26 |
| CHEMBL294156 | — | — | 1 | 4.95 |
| CHEMBL54632 | — | — | 1 | 4.86 |
| CHEMBL54814 | — | — | 1 | 4.85 |
| CHEMBL51694 | — | — | 1 | 4.85 |
| CHEMBL51750 | — | — | 1 | 4.73 |
| CHEMBL299529 | — | — | 1 | 4.70 |
| CHEMBL300465 | — | — | 1 | 4.69 |
| CHEMBL291461 | — | — | 1 | 4.66 |
| CHEMBL54419 | — | — | 1 | 4.66 |
| CHEMBL54949 | — | — | 1 | 4.38 |
| CHEMBL433486 | — | — | 1 | 4.28 |
| CHEMBL57397 | — | — | 1 | 4.16 |
| CHEMBL54490 | — | — | 1 | - |
| CHEMBL54861 | — | — | 1 | - |
| CHEMBL54362 | — | — | 1 | - |
| CHEMBL54530 | — | — | 1 | - |
| CHEMBL299948 | — | — | 1 | - |
| CHEMBL52018 | — | — | 1 | - |
| CHEMBL299412 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55032 | — | Ki | = | 149.97 | nM | 6.82 |
| CHEMBL56014 | — | Ki | = | 279.9 | nM | 6.55 |
| CHEMBL52034 | — | Ki | = | 330.37 | nM | 6.48 |
| CHEMBL55145 | — | Ki | = | 839.46 | nM | 6.08 |
| CHEMBL53413 | — | Ki | = | 849.18 | nM | 6.07 |
| CHEMBL53002 | — | Ki | = | 1399.59 | nM | 5.85 |
| CHEMBL54950 | — | Ki | = | 1949.84 | nM | 5.71 |
| CHEMBL54782 | — | Ki | = | 3499.45 | nM | 5.46 |
| CHEMBL293964 | — | Ki | = | 3999.45 | nM | 5.40 |
| CHEMBL54371 | — | Ki | = | 4197.59 | nM | 5.38 |
| CHEMBL441976 | — | Ki | = | 5495.41 | nM | 5.26 |
| CHEMBL294156 | — | Ki | = | 11297.96 | nM | 4.95 |
| CHEMBL54632 | — | Ki | = | 13803.84 | nM | 4.86 |
| CHEMBL54814 | — | Ki | = | 14190.58 | nM | 4.85 |
| CHEMBL51694 | — | Ki | = | 14092.89 | nM | 4.85 |
| CHEMBL51750 | — | Ki | = | 18620.87 | nM | 4.73 |
| CHEMBL299529 | — | Ki | = | 19998.62 | nM | 4.70 |
| CHEMBL300465 | — | Ki | = | 20417.38 | nM | 4.69 |
| CHEMBL291461 | — | Ki | = | 21877.62 | nM | 4.66 |
| CHEMBL54419 | — | Ki | = | 21978.6 | nM | 4.66 |
| CHEMBL54949 | — | Ki | = | 41686.94 | nM | 4.38 |
| CHEMBL433486 | — | Ki | = | 52722.99 | nM | 4.28 |
| CHEMBL57397 | — | Ki | = | 69023.98 | nM | 4.16 |
| CHEMBL53109 | — | Ki | = | 132129.56 | nM | - |
| CHEMBL53162 | — | Ki | = | 297851.64 | nM | - |
| CHEMBL298559 | — | Ki | = | 1949844.6 | nM | - |
| CHEMBL53209 | — | Ki | = | 464515.28 | nM | - |
| CHEMBL53228 | — | Ki | = | 3801893.96 | nM | - |
| CHEMBL299172 | — | Ki | = | 5128613.84 | nM | - |
| CHEMBL298952 | — | Ki | = | 1548816.62 | nM | - |
| CHEMBL299412 | — | Ki | = | 1879316.82 | nM | - |
| CHEMBL52018 | — | Ki | = | 177827.94 | nM | - |
| CHEMBL299948 | — | Ki | = | 3899419.87 | nM | - |
| CHEMBL54530 | — | Ki | = | 158124.8 | nM | - |
| CHEMBL54362 | — | Ki | = | 2187761.62 | nM | - |
| CHEMBL54861 | — | Ki | = | 119949.93 | nM | - |
| CHEMBL54490 | — | Ki | = | 199986.19 | nM | - |