Assay Detail
Binding
CHEMBL858267
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Inhibition of human dihydrofolate reductase (DHFR) enzyme
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Quantitative structure-activity relationships of the inhibition of Pneumocystis carinii dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(X-phenyl)-s-triazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.68 | 7.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33697 | — | — | 1 | 7.65 |
| CHEMBL280378 | EPIROPRIM | 2.0 | 1 | 7.23 |
| CHEMBL6666 | — | — | 1 | 7.11 |
| CHEMBL7130 | — | — | 1 | 7.03 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 6.71 |
| CHEMBL20587 | — | — | 1 | 6.66 |
| CHEMBL21254 | — | — | 1 | 6.52 |
| CHEMBL281618 | — | — | 1 | 6.11 |
| CHEMBL176987 | — | — | 1 | 6.01 |
| CHEMBL6742 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33697 | — | Ki | = | 22.39 | nM | 7.65 |
| CHEMBL280378 | EPIROPRIM | Ki | = | 58.88 | nM | 7.23 |
| CHEMBL6666 | — | Ki | = | 77.62 | nM | 7.11 |
| CHEMBL7130 | — | Ki | = | 93.33 | nM | 7.03 |
| CHEMBL22 | TRIMETHOPRIM | Ki | = | 194.98 | nM | 6.71 |
| CHEMBL20587 | — | Ki | = | 218.78 | nM | 6.66 |
| CHEMBL21254 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL281618 | — | Ki | = | 776.25 | nM | 6.11 |
| CHEMBL176987 | — | Ki | = | 977.24 | nM | 6.01 |
| CHEMBL6742 | — | Ki | = | 1659.59 | nM | 5.78 |