Assay Detail
Binding
CHEMBL858330
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Inhibitory activity against recombinant human matrix metalloprotease-13
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Analogue based design of MMP-13 (Collagenase-3) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 6.69 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276016 | — | — | 1 | 7.85 |
| CHEMBL10671 | — | — | 1 | 7.80 |
| CHEMBL10454 | — | — | 1 | 7.68 |
| CHEMBL10953 | — | — | 1 | 7.66 |
| CHEMBL10655 | — | — | 1 | 7.62 |
| CHEMBL10674 | — | — | 1 | 7.48 |
| CHEMBL10672 | — | — | 1 | 7.48 |
| CHEMBL10257 | — | — | 1 | 7.46 |
| CHEMBL275130 | — | — | 1 | 7.31 |
| CHEMBL11188 | — | — | 1 | 7.23 |
| CHEMBL274881 | — | — | 1 | 7.12 |
| CHEMBL10935 | — | — | 1 | 7.09 |
| CHEMBL91254 | — | — | 1 | 7.06 |
| CHEMBL91639 | — | — | 1 | 7.05 |
| CHEMBL10335 | — | — | 1 | 6.99 |
| CHEMBL10881 | — | — | 1 | 6.98 |
| CHEMBL10431 | — | — | 1 | 6.94 |
| CHEMBL10673 | — | — | 1 | 6.90 |
| CHEMBL10809 | — | — | 1 | 6.84 |
| CHEMBL10590 | — | — | 1 | 6.84 |
| CHEMBL10908 | — | — | 1 | 6.82 |
| CHEMBL275700 | — | — | 1 | 6.65 |
| CHEMBL10469 | — | — | 1 | 6.64 |
| CHEMBL10952 | — | — | 1 | 6.60 |
| CHEMBL10761 | — | — | 1 | 6.57 |
| CHEMBL10792 | — | — | 1 | 6.52 |
| CHEMBL10806 | — | — | 1 | 6.32 |
| CHEMBL10848 | — | — | 1 | 6.32 |
| CHEMBL274174 | — | — | 1 | 6.31 |
| CHEMBL10851 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276016 | — | IC50 | = | 14.13 | nM | 7.85 |
| CHEMBL10671 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL10454 | — | IC50 | = | 20.89 | nM | 7.68 |
| CHEMBL10953 | — | IC50 | = | 21.88 | nM | 7.66 |
| CHEMBL10655 | — | IC50 | = | 23.99 | nM | 7.62 |
| CHEMBL10674 | — | IC50 | = | 33.11 | nM | 7.48 |
| CHEMBL10672 | — | IC50 | = | 33.11 | nM | 7.48 |
| CHEMBL10257 | — | IC50 | = | 34.67 | nM | 7.46 |
| CHEMBL275130 | — | IC50 | = | 48.98 | nM | 7.31 |
| CHEMBL11188 | — | IC50 | = | 58.88 | nM | 7.23 |
| CHEMBL274881 | — | IC50 | = | 75.86 | nM | 7.12 |
| CHEMBL10935 | — | IC50 | = | 81.28 | nM | 7.09 |
| CHEMBL91254 | — | IC50 | = | 87.1 | nM | 7.06 |
| CHEMBL91639 | — | IC50 | = | 89.13 | nM | 7.05 |
| CHEMBL10335 | — | IC50 | = | 102.33 | nM | 6.99 |
| CHEMBL10881 | — | IC50 | = | 104.71 | nM | 6.98 |
| CHEMBL10431 | — | IC50 | = | 114.82 | nM | 6.94 |
| CHEMBL10673 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL10590 | — | IC50 | = | 144.54 | nM | 6.84 |
| CHEMBL10809 | — | IC50 | = | 144.54 | nM | 6.84 |
| CHEMBL10908 | — | IC50 | = | 151.36 | nM | 6.82 |
| CHEMBL275700 | — | IC50 | = | 223.87 | nM | 6.65 |
| CHEMBL10469 | — | IC50 | = | 229.09 | nM | 6.64 |
| CHEMBL10952 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL10761 | — | IC50 | = | 269.15 | nM | 6.57 |
| CHEMBL10792 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL10806 | — | IC50 | = | 478.63 | nM | 6.32 |
| CHEMBL10848 | — | IC50 | = | 478.63 | nM | 6.32 |
| CHEMBL274174 | — | IC50 | = | 489.78 | nM | 6.31 |
| CHEMBL10851 | — | IC50 | = | 758.58 | nM | 6.12 |
| CHEMBL11005 | — | IC50 | = | 870.96 | nM | 6.06 |
| CHEMBL10646 | — | IC50 | = | 1659.59 | nM | 5.78 |
| CHEMBL10492 | — | IC50 | = | 1698.24 | nM | 5.77 |
| CHEMBL407640 | — | IC50 | = | 2041.74 | nM | 5.69 |
| CHEMBL10822 | — | IC50 | = | 2137.96 | nM | 5.67 |
| CHEMBL10760 | — | IC50 | = | 2137.96 | nM | 5.67 |
| CHEMBL275345 | — | IC50 | = | 2754.23 | nM | 5.56 |
| CHEMBL275754 | — | IC50 | = | 3019.95 | nM | 5.52 |
| CHEMBL268050 | — | IC50 | = | 16982.44 | nM | 4.77 |