Assay Detail
Binding
CHEMBL858402
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards Dopamine receptor D3 (human cloned receptor) in CHO cells using [125I]iodosulpiride radioligand.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.93 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116448 | — | — | 1 | 6.20 |
| CHEMBL1788231 | — | — | 1 | 6.00 |
| CHEMBL333784 | — | — | 1 | 6.00 |
| CHEMBL94984 | — | — | 1 | 5.90 |
| CHEMBL12624 | SB-258741 | — | 1 | 5.90 |
| CHEMBL282199 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116448 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL1788231 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL333784 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL94984 | — | Ki | = | 1258.93 | nM | 5.90 |
| CHEMBL12624 | SB-258741 | Ki | = | 1258.93 | nM | 5.90 |
| CHEMBL282199 | — | Ki | = | 2511.89 | nM | 5.60 |