Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL858408

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Experimental anti-HDAC (anti-histone deacetylase) activity of the compound
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Zea mays
Confidence 9 — Direct single protein target
Curated By Expert

Target

Histone deacetylase HD2 (CHEMBL4919)
Type SINGLE PROTEIN
Organism Zea mays

Publication

3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors.
Massa S, Mai A, Sbardella G, Esposito M, Ragno R, Loidl P, Brosch G.
J Med Chem (2001) 44 : 2069 -2072
PubMed 11405644 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 10 6.39 8.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL99 TRICHOSTATIN 1.0 1 8.36
CHEMBL13235 1 8.36
CHEMBL98 VORINOSTAT 4.0 1 6.88
CHEMBL51356 1 5.95
CHEMBL51060 1 5.84
CHEMBL66584 1 5.84
CHEMBL62226 1 5.76
CHEMBL65733 1 5.64
CHEMBL13168 1 5.64
CHEMBL294808 1 5.63

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL99 TRICHOSTATIN Ki = 4.365 nM 8.36
CHEMBL13235 Ki = 4.365 nM 8.36
CHEMBL98 VORINOSTAT Ki = 131.83 nM 6.88
CHEMBL51356 Ki = 1122.02 nM 5.95
CHEMBL51060 Ki = 1445.44 nM 5.84
CHEMBL66584 Ki = 1445.44 nM 5.84
CHEMBL62226 Ki = 1737.8 nM 5.76
CHEMBL65733 Ki = 2290.87 nM 5.64
CHEMBL13168 Ki = 2290.87 nM 5.64
CHEMBL294808 Ki = 2344.23 nM 5.63