Assay Detail
Binding
CHEMBL858425
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity for glycine site on the NMDA receptor.
34
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Glutamate receptor ionotropic, NMDA 1 (CHEMBL330) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological evaluation of pyrido[2,3-b]pyrazine and pyrido[2,3-b]pyrazine-n-oxide as selective glycine antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 6.18 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL316319 | — | — | 1 | 6.96 |
| CHEMBL327343 | — | — | 1 | 6.95 |
| CHEMBL328571 | — | — | 1 | 6.95 |
| CHEMBL93473 | — | — | 2 | 6.84 |
| CHEMBL93164 | — | — | 1 | 6.73 |
| CHEMBL93165 | — | — | 1 | 6.72 |
| CHEMBL90253 | — | — | 1 | 6.69 |
| CHEMBL94018 | — | — | 1 | 6.68 |
| CHEMBL91698 | — | — | 1 | 6.65 |
| CHEMBL329176 | — | — | 1 | 6.55 |
| CHEMBL330190 | — | — | 1 | 6.43 |
| CHEMBL327178 | — | — | 1 | 6.37 |
| CHEMBL91801 | — | — | 1 | 6.37 |
| CHEMBL94925 | — | — | 1 | 6.34 |
| CHEMBL92845 | — | — | 1 | 6.33 |
| CHEMBL93837 | — | — | 1 | 6.30 |
| CHEMBL96359 | — | — | 1 | 6.29 |
| CHEMBL92456 | — | — | 1 | 6.29 |
| CHEMBL92282 | — | — | 1 | 6.27 |
| CHEMBL432648 | — | — | 1 | 6.13 |
| CHEMBL93062 | — | — | 1 | 6.09 |
| CHEMBL92143 | — | — | 1 | 6.04 |
| CHEMBL96878 | — | — | 1 | 5.82 |
| CHEMBL329680 | — | — | 1 | 5.80 |
| CHEMBL92674 | — | — | 1 | 5.80 |
| CHEMBL92080 | — | — | 1 | 5.75 |
| CHEMBL424246 | — | — | 1 | 5.56 |
| CHEMBL92084 | — | — | 1 | 5.54 |
| CHEMBL327344 | — | — | 1 | 5.52 |
| CHEMBL328357 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL316319 | — | Ki | = | 109.65 | nM | 6.96 |
| CHEMBL327343 | — | Ki | = | 112.2 | nM | 6.95 |
| CHEMBL328571 | — | Ki | = | 112.2 | nM | 6.95 |
| CHEMBL93473 | — | Ki | = | 144.54 | nM | 6.84 |
| CHEMBL93164 | — | Ki | = | 186.21 | nM | 6.73 |
| CHEMBL93165 | — | Ki | = | 190.55 | nM | 6.72 |
| CHEMBL90253 | — | Ki | = | 204.17 | nM | 6.69 |
| CHEMBL94018 | — | Ki | = | 208.93 | nM | 6.68 |
| CHEMBL91698 | — | Ki | = | 223.87 | nM | 6.65 |
| CHEMBL329176 | — | Ki | = | 281.84 | nM | 6.55 |
| CHEMBL330190 | — | Ki | = | 371.54 | nM | 6.43 |
| CHEMBL91801 | — | Ki | = | 426.58 | nM | 6.37 |
| CHEMBL327178 | — | Ki | = | 426.58 | nM | 6.37 |
| CHEMBL94925 | — | Ki | = | 457.09 | nM | 6.34 |
| CHEMBL92845 | — | Ki | = | 467.74 | nM | 6.33 |
| CHEMBL93837 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL92456 | — | Ki | = | 512.86 | nM | 6.29 |
| CHEMBL96359 | — | Ki | = | 512.86 | nM | 6.29 |
| CHEMBL92282 | — | Ki | = | 537.03 | nM | 6.27 |
| CHEMBL432648 | — | Ki | = | 741.31 | nM | 6.13 |
| CHEMBL93062 | — | Ki | = | 812.83 | nM | 6.09 |
| CHEMBL92143 | — | Ki | = | 912.01 | nM | 6.04 |
| CHEMBL96878 | — | Ki | = | 1513.56 | nM | 5.82 |
| CHEMBL329680 | — | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL92674 | — | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL92080 | — | Ki | = | 1778.28 | nM | 5.75 |
| CHEMBL93473 | — | Ki | = | 1905.46 | nM | 5.72 |
| CHEMBL424246 | — | Ki | = | 2754.23 | nM | 5.56 |
| CHEMBL92084 | — | Ki | = | 2884.03 | nM | 5.54 |
| CHEMBL327344 | — | Ki | = | 3019.95 | nM | 5.52 |
| CHEMBL328357 | — | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL92194 | — | Ki | = | 3715.35 | nM | 5.43 |
| CHEMBL92646 | — | Ki | = | 4677.35 | nM | 5.33 |
| CHEMBL27648 | — | Ki | = | 6165.95 | nM | 5.21 |