Assay Detail
Binding
CHEMBL858654
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Stimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Human P2Y(6) receptor: molecular modeling leads to the rational design of a novel agonist based on a unique conformational preference.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.49 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL130266 | URIDINE_DIPHOSPHATE | — | 1 | 7.07 |
| CHEMBL2113161 | — | — | 1 | 6.64 |
| CHEMBL9519 | — | — | 1 | 5.76 |
| CHEMBL9314 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL130266 | URIDINE_DIPHOSPHATE | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL2113161 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL9519 | — | EC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL9314 | — | EC50 | - | — | - |