Assay Detail
Functional
CHEMBL858716
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Inhibition of drug-resistant Plasmodium falciparum Dd2 after 72 hrs
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 4.47 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370595 | — | — | 1 | 5.50 |
| CHEMBL849 | TRICLOSAN | 4.0 | 1 | 5.41 |
| CHEMBL200450 | — | — | 1 | 5.27 |
| CHEMBL197274 | — | — | 1 | 5.25 |
| CHEMBL200609 | — | — | 1 | 4.75 |
| CHEMBL372323 | — | — | 1 | 4.69 |
| CHEMBL200514 | — | — | 1 | 4.51 |
| CHEMBL200322 | — | — | 1 | 4.47 |
| CHEMBL200533 | — | — | 1 | 4.44 |
| CHEMBL370448 | — | — | 1 | 4.37 |
| CHEMBL199081 | — | — | 1 | 4.36 |
| CHEMBL200492 | — | — | 1 | 4.34 |
| CHEMBL200585 | — | — | 1 | 4.32 |
| CHEMBL200658 | — | — | 1 | 4.29 |
| CHEMBL197322 | — | — | 1 | 4.11 |
| CHEMBL200871 | — | — | 1 | 4.08 |
| CHEMBL198831 | — | — | 1 | 4.06 |
| CHEMBL200379 | — | — | 1 | 4.06 |
| CHEMBL197111 | — | — | 1 | 4.03 |
| CHEMBL200308 | — | — | 1 | 4.02 |
| CHEMBL197474 | — | — | 1 | 4.00 |
| CHEMBL198887 | — | — | 1 | 4.00 |
| CHEMBL198781 | — | — | 1 | - |
| CHEMBL198782 | — | — | 1 | - |
| CHEMBL198886 | — | — | 1 | - |
| CHEMBL196818 | — | — | 1 | - |
| CHEMBL383166 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370595 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL849 | TRICLOSAN | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL200450 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL197274 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL200609 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL372323 | — | EC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL200514 | — | EC50 | = | 30600.0 | nM | 4.51 |
| CHEMBL200322 | — | EC50 | = | 33900.0 | nM | 4.47 |
| CHEMBL200533 | — | EC50 | = | 36400.0 | nM | 4.44 |
| CHEMBL370448 | — | EC50 | = | 42600.0 | nM | 4.37 |
| CHEMBL199081 | — | EC50 | = | 43700.0 | nM | 4.36 |
| CHEMBL200492 | — | EC50 | = | 45400.0 | nM | 4.34 |
| CHEMBL200585 | — | EC50 | = | 47500.0 | nM | 4.32 |
| CHEMBL200658 | — | EC50 | = | 50900.0 | nM | 4.29 |
| CHEMBL197322 | — | EC50 | = | 77500.0 | nM | 4.11 |
| CHEMBL200871 | — | EC50 | = | 83900.0 | nM | 4.08 |
| CHEMBL198831 | — | EC50 | = | 86400.0 | nM | 4.06 |
| CHEMBL200379 | — | EC50 | = | 87800.0 | nM | 4.06 |
| CHEMBL197111 | — | EC50 | = | 94500.0 | nM | 4.03 |
| CHEMBL200308 | — | EC50 | = | 95700.0 | nM | 4.02 |
| CHEMBL197474 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL198887 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL198781 | — | EC50 | > | 120000.0 | nM | - |
| CHEMBL198782 | — | EC50 | = | 120000.0 | nM | - |
| CHEMBL198886 | — | EC50 | > | 150000.0 | nM | - |
| CHEMBL196818 | — | EC50 | = | 130000.0 | nM | - |
| CHEMBL383166 | — | EC50 | = | 140000.0 | nM | - |