Assay Detail
Binding
CHEMBL858764
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of [3H]spiperone binding to the human dopamine receptor D3 expressed in CHO cells, expressed as 10log Ki
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
GRID/GOLPE 3D quantitative structure-activity relationship study on a set of benzamides and naphthamides, with affinity for the dopamine D3 receptor subtype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 6.90 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL168663 | — | — | 1 | 7.70 |
| CHEMBL30208 | — | — | 1 | 7.60 |
| CHEMBL442535 | — | — | 1 | 7.40 |
| CHEMBL436447 | — | — | 1 | 7.40 |
| CHEMBL30206 | — | — | 1 | 7.40 |
| CHEMBL416939 | — | — | 1 | 7.30 |
| CHEMBL29182 | — | — | 1 | 7.30 |
| CHEMBL355444 | — | — | 1 | 7.30 |
| CHEMBL169229 | — | — | 1 | 7.30 |
| CHEMBL28964 | — | — | 1 | 7.20 |
| CHEMBL166557 | — | — | 1 | 7.10 |
| CHEMBL30146 | — | — | 1 | 7.10 |
| CHEMBL168678 | — | — | 1 | 7.10 |
| CHEMBL167483 | — | — | 1 | 7.10 |
| CHEMBL169450 | — | — | 1 | 7.10 |
| CHEMBL168908 | — | — | 1 | 7.00 |
| CHEMBL169753 | — | — | 1 | 6.90 |
| CHEMBL169832 | — | — | 1 | 6.70 |
| CHEMBL167230 | — | — | 1 | 6.70 |
| CHEMBL353642 | — | — | 1 | 6.60 |
| CHEMBL29649 | — | — | 1 | 6.60 |
| CHEMBL165879 | — | — | 1 | 6.60 |
| CHEMBL29610 | — | — | 1 | 6.60 |
| CHEMBL283034 | — | — | 1 | 6.50 |
| CHEMBL169090 | — | — | 1 | 6.50 |
| CHEMBL354574 | — | — | 1 | 6.50 |
| CHEMBL168746 | — | — | 1 | 6.40 |
| CHEMBL168245 | — | — | 1 | 6.30 |
| CHEMBL352905 | — | — | 1 | 6.00 |
| CHEMBL168691 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL168663 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL30208 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL442535 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL436447 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL30206 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL416939 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL29182 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL355444 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL169229 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL28964 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL166557 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL30146 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL168678 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL167483 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL169450 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL168908 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL169753 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL169832 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL167230 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL353642 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL29649 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL165879 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL29610 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL283034 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL169090 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL354574 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL168746 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL168245 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL352905 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL168691 | — | Ki | = | 1584.89 | nM | 5.80 |